Abstract

Dental Fluorosis and Molar Incisor Hypomineralization cases prevalence in our Arabic children world are dramatically very high. Recent studies showed their bound relationship with dental caries incidence. While fluorosis showed association with high fluoride early life exposure, MIH etiological factors are still obscure. 

Fluoride hazards in recent years' studies in correlation with human health influence, implies the discussion of new innovative substitutes in dental caries prevention application models with proved encouraging positive international experience results.

Hydroxyapatite (HAp) preparation provides the same benefits of fluoride without exposing to its risks. It is a stable and biocompatible calcium phosphate evidenced since long with a crucial role in structural bone augmentation, besides that demonstrated potency in recent years through oral care agents with the same principle of enhancing enamel calcium-phosphate hydroxyapatite crystals build-up regeneration. Calcium glycerophosphate is another soluble agent that has shown its worth in actual practice in preventing erosive lesion eruption and arresting already existing white spots lesions and is labeled safe since long as a nutrient supplement mediator for buffering stomach acidity. This presentation narrative review articles aimed to summarize the recent findings of researches’ investigations into in vitro, vivo and situ studies of toothpaste and professional applied HAp/CGP agents’ competence on enamel remineralization scales versus fluoridated preparations.

Learning Objectives

• Fluorosis and MIH regional epidemiology and classification recognition.
• Understanding the relationship between fluorosis/MIH and tooth decay.
• Debates of fluoride hazards on human health impact researches’ presentation.
• New innovative biomimetics mineral’s mechanism of action and its biological role in enamel white spot lesion remineralization with clinical cases demonstration.
• Toothpaste and remineralizing agents’ comparative results as fluoride alternatives preparations.